Will you regain the weight when you stop Wegovy or Mounjaro?
What the research says about weight regain after stopping GLP-1 medicines, and what helps keep it off.
Large studies show that when people stop GLP-1 and dual-agonist medicines such as Wegovy (semaglutide) and Mounjaro (tirzepatide), much of the lost weight often returns over time, because appetite hormones return to how they were before treatment.
A major review published in The BMJ found people regained weight at roughly 0.4 kg (nearly 1 lb) a month after stopping, with many back at their starting weight within about 1.5 to 1.7 years.
That doesn't mean regain is inevitable for everyone. Ongoing changes to eating, activity and strength training, and continued support, give the best chance of keeping weight off. Talk to your prescriber before stopping, and about how to come off treatment.
This is general information about prescription medicines, not advice or a recommendation to use them. Speak to your prescriber or pharmacist about your own treatment.
Sources we checked
- Less than two years after stopping obesity drugs, weight and health issues return (Reuters, January 2026)
This article is general information, not medical advice. Speak to a doctor, pharmacist or other qualified clinician about your own health, especially before starting a supplement or if symptoms are new, severe or worrying.
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