Does the Wegovy pill work as well as the injection?
What the trials show about oral versus injectable semaglutide for weight loss.
Both contain semaglutide. A 2026 indirect comparison found that oral semaglutide 25 mg and injectable semaglutide 2.4 mg produced broadly similar weight loss. However, there hasn't been a direct head-to-head trial, so they shouldn't be described as identical in effectiveness.
This is general information about prescription medicines, not advice or a recommendation to use them. Speak to your prescriber or pharmacist about your own treatment.
Sources we checked
- Indirect comparison of oral and injectable semaglutide (2026) (PubMed)
- OASIS 4: oral semaglutide 25 mg in adults with overweight or obesity (New England Journal of Medicine)
This article is general information, not medical advice. Speak to a doctor, pharmacist or other qualified clinician about your own health, especially before starting a supplement or if symptoms are new, severe or worrying.
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